What Is Nexium (Esomeprazole)?
Nexium is the brand name for esomeprazole (an isomer of omeprazole). A drug which belongs to the class of proton pump inhibitors and is used to treat certain stomach and esophagus problems. It has found use in both duodenal and gastric ulcer.

Nexium is approved for use in the treatment of gastroesophageal reflux disease (GERD), and in combination with certain antibiotics like Clindamycin for the treatment of patients with H.pylori infection. It has found use in the treatment of Zollinger-Ellison syndrome.

Nexium relieves the persistent cough, heartburn and swallowing difficulty caused by acid reflux and heals the acid damage to the stomach and esophagus.. Other proton pump inhibitors, which block the production of acid in the stomach include: omeprazole (prilosec), rabeprazole (Aciphex), pantoprazole (Protonix)..

Nexium Dosage

The over-the-counter (OTC) Nexium is packaged in 20-milligram (mg) capsules. This version of Nexium should not be used more than 14 days at a stretch, unless directed by a physician.

Nexium capsules should be taken one hour before meals, swallowed whole and not to be crushed. Patients with difficulty swallowing can open capsule and mix with apple sauce.

Average prescription strength dosing is as follows, although your doctor may prescribe different doses for you:

For adults: 20 to 40 mg, once daily for four to eight weeks
For children (ages 1 to 11): 10 to 20 mg daily
For treatment of H. pylori: 40 mg, once daily along with amoxicillin (Amoxicot, Amoxil, Biomox) and clarithromycin (Biaxin), for 10 days.
Zollinger-Ellison syndrome: 40 mg, twice daily

Nexium Side Effects

Common Side Effects of Nexium (Esomeprazole)
Abnormal heartbeat
Leg cramps
High doses and long-term use may increase the risk of osteoporosis-related fractures of the hip, wrist, and spine.

Serious Side Effects of Nexium (Esomeprazole)
If you are experiencing any of the following, contact your doctor immediately.
Muscle weakness and limp feeling
Jerking muscle movements
Severe allergic reaction
Hoarseness or trouble swallowing
Uneven heart rate

Nexium Interactions

You should inform your doctor about any allergies associated with all the medications you take, whether otc (over-the-counter), vitamins, recreational drugs and herbal supplements as they can affect how Nexium works and vice-versa.
Nexium can potentiate the action of Valium (diazepam) in the body by increasing the plasma drug concentration which could lead to deleterious adverse reactions. The two medications must not be used together.

There can also be event of drug toxicity when Nexium is taken alongside digoxin( Lanoxin) as a result of increase in the absorption of the drug. Also, Nexium may increase blood levels of saquinavir (Fortovase) and reduce levels of nelfinavir (Viracept), so doctors should avoid prescribing these medications together.
Using Nexium with the following medications should also be avoided.
Iron supplements
Certain HIV medications
Blood thinners
Cilostazol (Pletal)
Certain antifungals

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